Changes in human meibum lipid with meibomian gland dysfunction using principal component analysis
نویسندگان
چکیده
منابع مشابه
Differences in human meibum lipid composition with meibomian gland dysfunction using NMR and principal component analysis.
PURPOSE Nuclear magnetic resonance (NMR) spectroscopy has been used to quantify lipid wax, cholesterol ester terpenoid and glyceride composition, saturation, oxidation, and CH₂ and CH₃ moiety distribution. This tool was used to measure changes in human meibum composition with meibomian gland dysfunction (MGD). METHODS (1)H-NMR spectra of meibum from 39 donors with meibomian gland dysfunction ...
متن کاملHuman meibum lipid conformation and thermodynamic changes with meibomian-gland dysfunction.
PURPOSE Instability of the tear film with rapid tear break-up time is a common feature of aqueous-deficient and evaporative dry eye diseases, suggesting that there may be a shared structural abnormality of the tear film that is responsible for the instability. It may be that a change in the normal meibum lipid composition and conformation causes this abnormality. Principle component analyses of...
متن کاملMeibum Color and Free Fatty Acid Composition in Patients With Meibomian Gland Dysfunction.
PURPOSE We measured the components of meibum in patients with meibomian gland dysfunction (MGD) and control subjects and then examined the relation between meibum composition and clinical parameters. METHODS Thirty-eight patients with MGD (13 men and 25 women; mean age ± SD, 66.9 ± 15.0 years) and 20 control subjects (8 men and 12 women; 64.5 ± 6.7 years) were enrolled. Ocular symptom score, ...
متن کاملChanges in gene expression in human meibomian gland dysfunction.
PURPOSE Meibomian gland dysfunction (MGD) may be the leading cause of dry eye syndrome throughout the world. However, the precise mechanism(s) underlying the pathogenesis of this disease is unclear. This study was conducted to identify meibomian gland genes that may promote the development and/or progression of human MGD. METHODS Lid tissues were obtained from male and female MGD patients and...
متن کاملAnalysis of the composition of lipid in human meibum from normal infants, children, adolescents, adults, and adults with meibomian gland dysfunction using ¹H-NMR spectroscopy.
PURPOSE This study represents a first step toward the evaluation of possible compositional differences in meibum from normal donors (Mn) and donors with meibomian gland dysfunction (Md) by (1)H-NMR spectroscopy. The results highlight the applicability of (1)H-NMR spectroscopy for the quantitative analysis of waxes, cholesteryl esters, and glycerides in meibum lipid (ML). METHODS Meibum was ob...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2010
ISSN: 0014-4835
DOI: 10.1016/j.exer.2010.05.014